Plateau environment has the characteristic of low oxygen and low pressure,which leads to a series of physiological changes and affects the process of drug metabolism in the body.Many factors affect the pharmacokinetic parameters,including gastric emptying, blood rheology, cardiopulmonary function,hepatorenal function,cytochrome P450 enzyme and so on. The present study focuses on drug metabolic enzymes,since drug transporter is the key factor that mediates drugs in their entrance to the body through the cell...
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