【摘要】 目的:探讨单倍体相合造血干细胞移植(haploidentical-HSCT,hi-HSCT)治疗再生障碍性贫血(AA)后急性移植物抗宿主病(aGVHD)与移植物成分的关系。方法:回顾性分析57例AA行hi-HSCT的患者,按有无发生Ⅱ-Ⅳ度aGVHD分组,比较2组移植物成分的作用,以分析移植后发生Ⅱ-Ⅳ度aGVHD与移植物成分的关系。结果:57例患者中,14例发生Ⅱ-Ⅳ度aGVHD,43例未发生Ⅱ-Ⅳ度aGVHD。2组的有核细胞计数、CD3~+、CD4~+、CD8~+、NK细胞、NKT细胞、B细胞、Treg细胞数比较后均无统计学差异(P> 0. 05)。发生与未发生Ⅱ-Ⅳ度aGVHD组的CD34~+数分别为为3. 85(1. 73-10. 61)×10~6/kg和6. 31(2. 98-19. 35)×10~6/kg (P <0. 05)。结论:单倍体相合造血干细胞移植治疗再生障碍性贫血后发生Ⅱ-Ⅳ度aGVHD可能与CD34~+有关。更多还原

【Abstract】 Objective: To investigate the relationship between acute graft-versus-host disease and graft composition in patients with aplastic anemia(AA) after haploidentical hematopoietic stem cell transplantation. Methods : Fifty-seven cases of A A after haplo identical hematopoietic stem cell transplantation were retrospectively analyzed. All the patients were divided into 2 groups according to whether presence or absence grade Ⅱ-Ⅳ aGVHD, the relationship between aGVHD and graft composition was analyzed by comparing the differences of graft components between the 2 groups.Results: Fourteen out of 57 patients had grade Ⅱ-Ⅳ aGVHD and the other 43 did not have grade Ⅱ-Ⅳ aGVHD.The mononuclear cells,CD3~+,CD4~+,CD8~+,NK cells,NKT cells,B cells and Treg cells were not significantly different between the 2 groups(P >0.05), the CD34~+ cell count in the patients with grade Ⅱ-Ⅳ aGVHD was 3. 85(1.73-10.61) ×10~6/kg, which was significantly lower than that without grade Ⅱ-ⅣaGVHD: 6.31(2.98-19.35)× 10~6/kg(P<0.05). Conclusions: The incidence of grade Ⅱ-Ⅳ aGVHD may be related with CD34~+ cell count in A A after haploidentical hematopoietic stem cell transplantation.更多还原