Total paeony glycoside(TPG) is obtained from Radix Paeoniae Rubra with a variety of bioactivities. However, the low solubility and bioavailability limit its application. The present study aimed to develop TPG nanocrystals to increase the dissolution and then improve the oral bioavailability. TPG nanocrystals were prepared via precipitation and high-pressure homogenization method. The physical-chemical properties of the optimal TPG nanocrystals in terms of particle size, zeta potential, morphology and crysta...
【基金】
Innovation Team Project(Grant No.LT2015011)from the Education Department of Liaoning Province;
Important Sci entific and Technical Achievements Transformation Project(Gr ant No.Z17-5-078);
Applied Basic Research Project(Grant No.F16205144)of Science and Technology Bureau of Shenyang;
the Liaoning Provincial Education Department Project of China(Grant No.L2015192)
【更新日期】
2018-03-19
【分类号】
R283.6
【正文快照】
1.IntroductionRadix Paeoniae Rubra,dried root with bark usuallycollected from the wild Paeonia lactiflora Pallas[1,2],is oneof the ancient traditional Chinese herbal medicines withproperties of heat-clearing,blood-cooling,stasis-dissipatingand analgesic e
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