Atherosclerosis is a chronic inflammatory disease. Chronic aseptic inflammation in vascular endothelial cells,particularly the inflammasome pathway,is involved in the injury of the vascular endothelium. NLRP3 protein is the macromolecular polyprotein complex which is the nucleotide-binding oligomerization domain,leucine rich repeat and pyrin domain containing proteins binding to the apoptosisassociated speck-like protein and the caspase-1 precursor. As a pattern recognition receptor,NLRP3 protein participat...
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