【摘要】 毛囊作为唯一的一个终生呈周期性生长的微器官,其生长、代谢都处于一个相对活跃的状态。毛发是由毛囊生长发育后的终末分化细胞构成,是一个持续不断生长的结构。毛发的生长依赖于毛囊结构干细胞特性的分裂、增殖、分化,因此毛发生长的形态变化取决于毛囊结构生长发育的情况。随着研究方法的不断进步与更新,近年来针对毛发弯曲性状分子遗传学层面的研究进展较迅速,一些影响毛囊形态发育和毛发弯曲过程的基因和调控通路相继被发现和鉴定。本文旨在先通过对毛囊结构及其形态发生特点的剖析,进一步对近年来毛囊各细胞层在毛发弯曲产生的影响和特异性调控基因的相关研究进行归纳,绘制出与毛囊发育相关的经典通路和相关调控基因的互作网络,为今后对羊毛弯曲动态现象的分子机理研究提供参考。更多还原

【Abstract】 As the only micro organ,the hair follicles grow periodically throughout life,hair follicle is in a relatively active growing and metabolic state.Hair shaft is a sustained developing structure that consists of hair follicle’s terminally differentiated cells.The morphological change of hair shaft depends on the structural development of hair follicle,since mitosis,proliferation and differentiation of hair follicle stem cells determine the growth of hair fibre.In recent years,thanks to the improvement and innovation of research methods,great progresses have been made rapidly on studies of hair curvature at the molecular genetics level,and some genetic factors and signal pathways have been uncovered and verified,which act on hair follicle development and hair wave patterns.We introduced the anatomical and morphogenetic properties of hair follicle,and then generalized research advances of hair curvature on the basis of hair follicle’s different cell layers and their specific regulatory genes;finally,we also described an interaction network among thecanonical pathways and genes related to hair follicle development.The review was presented in order to provide references for the study on molecular mechanisms of wool curling in a dynamic morphogeny.更多还原