【摘要】 目的探讨缬沙坦对下肢动脉硬化闭塞症介入术后再狭窄的影响。方法接受股浅动脉支架植入术的连续98例下肢动脉硬化闭塞症合并高血压患者,随机分为观察组和对照组,每组49例,2组患者均给予常规抗血小板治疗,观察组在此基础上加用缬沙坦。随访6个月比较2组患者治疗前后临床疗效、踝肱指数(ABI),高敏C反应蛋白(hs-CPR)血浆水平及再狭窄率。结果 6个月后临床有效率观察组总效率为97.9%,对照组总有效率为83.3%(P<0.05);2组患者治疗后ABI较治疗前升高,观察组较对照组升高明显(P<0.05);hs-CRP观察组较对照组降低明显(P<0.05),观察组患者再狭窄率为10.2%;对照组再狭窄率29.2%(P<0.05)。结论缬沙坦对下肢动脉硬化闭塞症患者股动脉介入术后hs-CRP的产生有抑制作用,改善临床疗效,降低再狭窄率。更多还原

【Abstract】 Objective To investigate the effect of valsartan on the lower extremity atherosclerotic occlusive disease after intervention operation. Methods 98 inpatients with lower extremity atherosclerotic occlusive disease were randomly divided into observation group and control group, each group with 49 cases. The observation group was given valsartan on the basis of routine treatment, the treatment course was 6 months. The serum hs-CPR level, the change of ABI, restenosis rate and clinical curative effect in the two groups before and after the treatment were compared. Results After the treatment, Clinical curative effect of observation groupsand control groups were 97.9% and 83.3%, respectively, the difference was significant between the groups(P<0.05). The improvement effect of hs-CPR level in the observation group was better than that in control group, there was significant difference between the two groups(P<0.05). The restenosis rate level in the observation group was lower than that in control group, there was significant difference between the two groups(P<0.05), the improvement effect of ABI in the observation group was better than that in control group, there was significant difference between the two groups(P<0.05). Conclusions Valsartan in treating the lower extremity atherosclerotic occlusive disease after intervention operation call increase ABI, well decrease the serum level hs-CPR level and restenosis rate of the patients obviously, and improve the efficiency of clinical treatment.更多还原