【摘要】 目的:探讨子宫颈癌骨转移的核素显像特征及其发生的危险因素。方法:收集2011年1月至2016年12月期间我院确诊为子宫颈癌的患者经⁹⁹Tc^m-MDP全身骨显像及相关检查确诊为骨转移的患者135例（骨转移组）,观察子宫颈癌骨转移的核素显像特征及临床病理特征。选择同期连续收治的150例未发生骨转移的子宫颈癌患者（无骨转移组）作为对照。结果:。子宫颈癌骨转移的发生部位以骨盆最多见,脊柱次之,最后为胸部骨和四肢骨。涉及骨盆转移的91例（67.4%）。对骨转移组和非骨转移组患者的临床病理特征进行单因素分析,结果显示子宫颈癌骨转移的发生与初诊年龄、病理类型、血清肿瘤标志物异常无关（P>0.05）;而与临床分期、病理分级、血清碱性磷酸酶异常、血清钙或磷异常明显相关（P<0.05）。结论:子宫颈癌骨转移一般发生在确诊子宫颈癌后3年内,发生部位以骨盆最多见;肿瘤分期越晚、血清碱性磷酸酶异常的患者更容易发生骨转移。更多还原

【Abstract】 Objective:To discuss the radionuclide imaging features and risk factors for bone metsatasis in cervical cancer paitents.Methods:The radionuclide imaging features and clinical characteristics of 135 patients of cervical cancer patients with bone metastasis through in our hospital from January 2011 to december 2016 were studied retrospectively.The clinicopathologic characteristics were analyzed by univariate and multivariate analysis.Results:Pelvis was the most frequently involved metastatic site,followed by spine, thoracic bones. 91 cases(67.4%) had bone metastasis include pelvis.Univariate analysis showed that age, pathological type,abnormal tumor markers were not significant effect on bone metastasis(P>0.05).But clinical stage,pathological grading,abnormal serum ALP,abnormal serum Ca or P were significantly correlated with bone metastasis(P<0.05).Multivariate analysis showed thatclinical stage and abnormal serum ALP were independent risk factors for bone metastasis of cervical cancer(P<0.05).Conclusion:Bone metastasis was mostly occurs within 3 years afterdiagnosis of cervical cancer,pelvis was the most common site.The later clinical stage,abnormal serum ALP were more likely to have bone metastasis.更多还原