【摘要】 目的对女童快速型中枢性性早熟的早期预警和随访标志物进行分析与探究。方法本次研究选取本院2014年6月-2017年1月期间在我院就诊的132新发的性早熟女童患者作为研究对象,根据发病特点分为快速进展型中枢性性早熟组和缓慢进展型性早熟组,对两组患者的相应的生理指标进行比较,同时对两组患者在随访过程中各指标的变化的幅度进行比较,对可能导致中枢性性早熟的快速进展指标进行发现和分析。结果快速进展组黄体峰值/卵泡峰值、黄体值、促卵泡激素值、胰岛素生长因子、体重指数分别为0.2±0.08、0.70±0.03 m IU/ml、3.87±0.01 m IU/ml、1.12±0.57 m IU/ml、28.72±1.83 kg/m2,缓慢进展组各相应指标分别为0.1±0.03、0.21±0.01m IU/ml、2.83±0.02 m IU/ml、0.45±0.05 m IU/ml、25.45±1.45 kg/m~2,两组与实际差值存在统计学差异(P<0.05);随访半年后对两组的相关指标进行观察发现身高、黄体值、促卵泡激素值、乳房分析体重指数变化和骨龄与实际差值两组对比存在显著的差异(P<0.05)。结论黄体峰值/卵泡峰值、黄体值、促卵泡激素值、胰岛素生长因子、体重指数和骨龄与实际差值指标可以作为快速进展型中枢性性早熟的早期预警提示指标。更多还原

【Abstract】 Objective To analyze and explore the early warning and follow-up markers for rapid central precocious puberty in girls. Methods 132 cases of girls newly diagnosed with precocious puberty in our hospital from June,2014 to January,2017 were selected as the subjects. According to the morbidity characteristics,they were divided into rapidly progressive central precocious puberty group and slowly progressive precocious puberty group. The corresponding physiological indexes and the changes of indicators in the follow-up process of the two groups of patients were compared,and the indicators that might lead to rapidly progressive central precocious puberty were to be discovered and analyzed. Results The peak of corpus luteum/follicle,corpus luteum,follicle stimulating hormone,insulin growth factor and body mass index in the rapidly progressive group were respectively 0. 2 ± 0. 08,0. 70 + 0. 03 m IU/ml,3. 87 ± 0. 01 m IU/ml,1. 12 + 0. 57 m IU/ml and28. 72 ± 1. 83 kg/m2. The corresponding indexes in the slow progress group were respectively 0. 1 ± 0. 03,0. 21 ± 0. 01 m IU/ml,2. 83 ± 0. 02 m IU/ml,0. 45 ± 0. 05 m IU/ml,25. 45 ± 1. 45 kg/m2. And there was significant difference between the two groups( P < 0. 05). After six months of follow-up,observation of the related indexes of the two groups showed that there were significant differences in the changes of height,corpus luteum,follicle stimulating hormone,body mass index( BMI),and bone age and actual difference between the two groups( P < 0. 05). Conclusion The peak of corpus luteum/follicle,corpus luteum,follicle stimulating hormone,insulin growth factor,body mass index,bone age and actual difference indexes can be used as an early warning indicator for rapidly progressive central precocious puberty.更多还原