【摘要】 目的 :分析哮喘患儿血清25-羟维生素D[25(OH)D]水平与哮喘急性发作程度的相关性。方法 :选取我院2015年3月至2017年4月住院的113例哮喘发作期患儿入观察组,并选取同期80名健康体检儿童入对照组。检测两组受试儿童血清25(OH)D水平以及肺功能指标,并按照观察组患儿急性发作程度,再分为轻度组、中度组、重度组,运用Pearson法,分析25(OH)D水平与患儿肺功能及急性发作程度的相关性。结果 :观察组血清25(OH)D水平低于对照组,其维生素D缺乏率、维生素D不足率亦高于对照组,差异有统计学意义(P<0.05)。随着患儿哮喘急性发作程度的加重,其血清25(OH)D水平逐渐降低,FEF25、FEF50、FEF75亦逐渐下降,差异有统计学意义(P<0.05)。哮喘患儿血清25(OH)D水平与FEF25、FEF50、FEF75均呈正相关(P<0.05)。结论 :哮喘患儿血清25(OH)D水平的下降伴随着肺功能损伤的加重以及急性发作程度的上升,根据患儿血清25(OH)D水平适当补充维生素D,对于哮喘的预防与病情控制具有一定价值。更多还原

【Abstract】 Objective: The objective of this study was to analyze the correlations between the level of serum 25-hydroxyvitamin D [25(OH)D] and the severity of acute attack in children with asthma. Methods: A sample of 113 cases of asthma attack children in our hospital from March 2015 to April 2017 were selected into the observation group, and 80 healthy children in the same period were enrolled in the control group. The levels of serum 25(OH)D and the indexes of pulmonary function were detected in two groups of children. According to the severity of acute attack of children in the observation group, they were divided into mild group, moderate group and severe group. The correlations between the level of serum 25(OH)D and the severity of acute attack in children with asthma were analyzed by Pearson. Results: The level of serum 25(OH)D in the observation group was lower than that of the control group, and the deficiency rate of vitamin D and the inadequate rate of vitamin D were higher than those of the control group, the differences were statistically significant(P<0.05). With the aggravation of acute attack of asthma in children, the level of serum 25(OH)D decreased gradually, and FEF25, FEF50 and FEF75 also decreased gradually, the differences were statistically significant(P<0.05). The level of serum 25(OH)D was positively correlated with FEF25, FEF50 and FEF75 in children with asthma(P<0.05). Conclusion: The decrease of serum 25(OH)D level in children with asthma is accompanied by the aggravation of pulmonary function injury and the increase of acute attack severity. Supplymentation of vitamin D according to the level of serum 25(OH)D in children is of certain value for the prevention and control of asthma.更多还原