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深圳市男男性接触者HIV/AIDS疾病进展与KIR/HLA基因多态性关系研究

The association between MSM HIV/AIDS disease progression and KIR/HLA typing in Shenzhen

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【作者】 刘小敏刘莹周杰张桂欣郭聪锐

【Author】 LIU Xiao-min;LIU Ying;ZHOU Jie;ZHANG Gui-xin;GUO Cong-rui;Center for Disease Control and Prevention of Futian;

【机构】 深圳市福田区疾病预防控制中心

【摘要】 目的对深圳市男男性接触者(MSM)艾滋病病毒(HIV)感染者和艾滋病(AIDS)病人KIR/HLA不同基因型的分布及其与疾病进展的相关性进行研究。方法对329例MSM HIV/AIDS的KIR和HLA-B等位基因进行分型,分析KIR/HLA基因型与AIDS疾病进展的相关性。结果 329例MSM HIV/AIDS,典型进展组(TP)270例(82.07%),缓慢进展组(SP)59例(17.93%)。在SP组优势基因型是KIR 3DL1,57例(96.61%)和KIR2DL3,59例(100%),2组比较均有统计学差异(P<0.05),HLA-BW4/BW4纯合子和KIR3DL1/HLA-BW4联合表达SP组分别有11例(18.64%)和38例(64.41%),SP分布大于TP组(P<0.05)。结论 KIR/HLA对MSM感染HIV后病程进展有相关性,KIR3DL1、KIR2DL3、HLA-BW4/BW4纯合子及KIR3DL1/HLA-BW4联合表达,可能是延缓HIV感染者疾病进展的保护性因素。

【Abstract】 Objective To study the KIR/HLA genotypes distribution in MSM HIV/AIDS and its relevance to disease progression in Shenzhen. Methods KIR/HLA genotypes among 329 cases of MSM were determined and and the correlation between KIR/HLA genotype and AIDS disease progression were analyzed. Results The TP population accounted for 270 cases(82.07%), and the SP population accounted for 59 cases(17.93%) among 329 cases MSM HIV/AIDS. The KIR3DL1 and KIR2DL3 were the preponderant genotypes in SP group(P <0.05), their frequencies were 57 cases(96.61%) and 59 cases(100%). The frequencies of HLA-BW4/BW4 and KIR3DL1/HLA-BW4 in SP group were higher than that in TP group(P<0.05). Their frequencies were 11 caese(18.64%) and 38 cases(64.41%). Conclusion KIR/HLA polymorphism has an influence on MSM HIV/AIDS disease progression. KIR3DL1, KIR2DL3, HLA-BW4/BW4 and KIR3DL1/HLA-BW4 genotypes may be protective factors for delaying the progression of HIV infection.

【关键词】 艾滋病KIRHLA-B疾病进展
【Key words】 Acquired immunodeficiency syndromeKIRHLA-BDisease progression
【基金】 深圳市科技创新委基础研究项目(JCYJ20160428151927109)
  • 【文献出处】 现代预防医学 ,Modern Preventive Medicine , 编辑部邮箱 ,2018年10期
  • 【分类号】R512.91
  • 【被引频次】1
  • 【下载频次】108
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