【摘要】 目的调查膝关节骨性关节炎(osteoarthritis,OA)常见的影响因素。方法采用病例对照研究方法,严格按照制定的纳入排除标准选取病例137例,对照148例,通过面对面问卷调查的形式收集影响OA发生的相关资料。采用SPSS20.0软件进行统计分析。结果单因素分析结果表明BMI、家族史、关节外伤史、工作姿势、吸烟、饮酒、居住楼梯房、出行方式、规律的伸展运动以及服用钙制剂与OA发生有关联(P<0.05)。进一步进行多因素条件Logistic回归分析,6个变量有统计学意义:BMI≥28(OR=9.437,95%CI=2.915~30.351),家族史(OR=9.300,95%CI=1.939~44.594),吸烟(OR=4.310,95%CI=1.575~11.794),居住≥4层的非电梯楼房(OR=4.307,95%CI=1.766~10.506),出行方式为骑自行车(OR=0.035,95%CI=0.006~0.195)和钙制剂(OR=2.517,95%CI=1.227~5.167)。结论 BMI≥28、有OA家族史、吸烟和居住≥4层的非电梯楼房是OA发生的独立危险因素,出行方式为骑自行车是OA的独立保护因素。更多还原

【Abstract】 Objective The aim of this study was to investigate the influencing factors of knee osteoarthritis(OA).Methods In this study,137 patients with knee osteoarthritis and 148 controls were selected according to the inclusion and exclusion criteria.A case-control study was used and all subjects were subjected to the face-to-face questionnaire surveys.SPSS 20.0 was used for statistical analysis.Results Univariate analysis showed that BMI,family history,history of joint-injury,working posture,smoking,drinking,residential status,travel mode,stretching exercises regularly and calcium supplements were associated with OA(P <0.05).Multivariate conditional logistic regression analysis further showed that 6 factors were of significance,including BMI ≥28(OR =9.437,95% CI =2.915-30.351),family history(OR =9.300,95% CI =1.939-44.594),smoking(OR=4.310,95%CI=1.575-11.794),residential status(≥4 floors building that without elevator)(OR=4.307,95%CI=1.766-10.506),travel mode(cycling)(OR=0.035,95%CI=0.006-0.195) and calcium supplements(OR=2.517,95%CI=1.227-5.167).Conclusion BMI ≥28,family history,smoking and residential status(≥4 floors building that without elevator) were independent risk factors of OA.Travel mode(cycling) was an independent protective factor of OA.更多还原