BACKGROUND: Nanosized cell-type tissue-engineered bone is a good scaffold material possessing the merits of stem cells and nanomaterials to fabricate bone and soft tissue formation. OBJECTIVE: To explore the method of constructing nano-sized cell-type tissue-engineered bone and to explore its application in the repair of mandibular bone defects. METHODS: One New Zealand white rabbit was taken to isolate bone marrow stromal stem cells by centrifugation. Then, the cells were induced to differentiate into oste...