In this paper, the effect of exogenous miR-146 a on high-fat diet-induced chronic inflammation and insulin resistance in mice was investigated. The mice models were fed with a high-fat diet(HFD, 45% calories from fat) for 18 weeks. The adenovirus products(30 μL) were injected into mice tail veins since the 5 th week, which were carried out every 3-week for 5 total injections. Then glucose tolerance tests(GTT) and insulin tolerance tests(ITT) were conducted for the mice model during the 17 th and 18 th weeks...
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