【摘要】 目的:内皮型一氧化氮合酶(eNOS)主要表达于血管内皮细胞中,是保护心血管系统的重要酶,当病理刺激因素作用于血管时,eNOS发生脱偶联,导致心血管疾病的发生发展。目前已明确的脱偶联机制包括四氢生物蝶呤(BH4)缺乏、L-精氨酸缺乏、锌指结构破坏、谷胱甘肽化、乙酰化、蛋白质-蛋白质相互作用及氮氧化合物4(NOX4)与内质网应激,本文就此内容进行综述。更多还原

【Abstract】 Endothelial nitric oxide synthase(eNOS)is mainly expressed in vascular endothelial cells.It is an important enzyme to protect the cardiovascular system.When the pathological stimulant factors play a role in blood vessels,eNOS is deformed and leads to the development of cardiovascular disease.Are now clear to take off the coupling mechanisms include four hydrogen biopterin(BH4)lack,lack of L-arginine,zinc finger structure damage,glutathione,acetylation,protein-protein interactions,and nitrogen oxides 4(NOX4)and endoplasmic reticulum stress,this paper summarized on the content.更多还原