[Background] Vps74/GOLPH3 is a key protein involved in the glycosylation of the Golgi protein, and an important phosphatidylinositol-4-kinase effector and phosphatidylinositol-4-phosphate sensor participating in a variety of intracellular signaling pathways. [Objective] To characterize the Vps74/GOLPH3 homologue in Candida albicans and investigate the role of Cavps74 in stress response, secretion, morphogenesis and pathogenicity. [Methods] Sequence alignment and analysis were performed by the relevant bioso...
(Key Laboratory of Molecular Microbiology and Technology,Ministry of Education,Department ofMicrobiology,Nankai University,Tianjin 300071,China)白假丝酵母(Candida albicans)是临床上重要的条件致病性真菌,普遍存在于健康人群的口腔、肠道、阴道及泌尿系统中。一般
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