【摘要】 目的:探讨噻托溴胺联合肺康复治疗稳定期慢性阻塞性肺疾病的疗效。方法:选取我院2013年6月～2014年10月收治的急性加重期慢性阻塞性肺疾病(COPD)患者经过治疗达到稳定期出院患者72例,按照数字随机法分为两组,对照组(出院后给予常规药物治疗) 36例,观察组(常规药物治疗+吸入噻托溴胺18μg/吸,1吸/日+肺康复治疗) 36例,疗程12个月,随访24个月。比较两组治疗前后改良版英国医学研究委员会呼吸问卷(mMRC)评分、慢阻肺患者自我评估测试问卷(CAT)评分及6分钟步行距离,肺功能改善情况,再住院率。结果:与对照组比较,观察组mMRC评分、CAT评分均降低,6分钟步行距离增加,再住院次数降低,FEV1、FEV1/FVC比值均升高(P均<0. 05);观察组治疗总有效率高于对照组(P<0. 05)。结论:噻托溴胺联合肺康复治疗稳定期慢性阻塞性肺疾病的疗效更佳,肺功能改善显著。更多还原

【Abstract】 Objective: To evaluate the clinical efficacies of combined tiotropium bromide with pulmonary rehabilitation for patients with stable chronic ob-structive pulmonary disease( COPD).Methods: Seventy-two cases of stable COPD treated in our hospital were included from June 2013 to October 2014,and divided into two group by random digital table.Patients in the control group( n = 36) received conventional medication after discharge,and those in theobservational group( n = 36) were treated with inhalation of tiotropium bormide in dose of 18 μg,once a day,plus pulmonary rehabilitation on conventionaldrug therapy basis.The treatment courses were 12 months,and all patients were followed for 24 months.Then two groups were compared regarding the im-provement of pulmonary function based on the scoring on the modified version of the British medical council respiratory questionnaire( mMRC) and chronicobstructive pulmonary disease self-assessment questionnaire( CAT),and distance of 6-min walk before and after therapy as well as the rate of re-admission.Results: Patients in the observational group had lower scores on m MRC and CAT,increased distance of 6-min walk,reduced rate of re-admission,elevatedFEV1,FEV1/FVC ratio( all P < 0. 05). The total effective rate was significantly higher in observational group than that in control group( P < 0. 05).Conclusion: Combined tiotropium bromide with pulmonary rehabilitation can be better efficacy for patients with stable COPD,and significantly improvetheir pulmonary function.更多还原