【摘要】 乙型肝炎病毒HBV是威胁中国人民健康最主要的疾病之一,约60-70%的人群都携带有HBV感染。HBV可致急、慢性乙型肝炎,造成肝纤维化、肝硬化,最终发展成为肝细胞癌。HBV病毒的x基因是其基因组中最小却最重要的开放读码框。其编码合成的HBX蛋白不会分泌到细胞外,而是留在细胞中发挥着反式激活的功能,调节细胞信号通路,进而对细胞的形态学和生物学状态产生不良影响,最终导致肝脏的一系列病理性改变。对此,本篇综述旨在从最基本的细胞层面,对HBX致感染细胞生物学活性改变的相关研究内容作一个全面的综述,以期为后续的肝脏疾病进展机制研究奠定一个根本的全面的理论基础。更多还原

【Abstract】 Hepatitis B virus is one of the greatest health problems in China and there is approximately 60-70% of the population infected by HBV virus, which will cause acute or chronic Hepatitis B disease, leading the way to liver fibrosis, cirrhosis, and finally hepatocellular carcinoma(HCC). HBV-x gene is the smallest but most important ORF of HBV genome. Instead of entering the blood circulation, HBX protein stays within the target cell, exerts functions as transactivating the cells or regulating the signal pathway, and thus has bad effects on morphological and biological situation of the cells. As a result, HBx leads to a series of hepatic pathological changes progressively. Referring to this, this review is going to make an informative aggregation to indicate the effects of HBX on hepatocytes’ biological characteristics at cellular level, in order to lighting up the way along the following mechanism studies on liver disease progression.更多还原