【摘要】 类风湿关节炎(rheum atoid arthritis RA)是一种伴随滑膜持续炎症和关节软骨及骨破坏的慢性自身免疫性疾病,其发病机制与多种细胞因子有着密切的关系。白细胞介素-17(IL-17或IL-17A)是由T辅助(Th)17细胞产生的多效性细胞因子,参与包括类风湿关节在内的各种自身免疫和炎性疾病的发病机理。IL-17在RA发病中的重要作用越来越受重视。IL-17对类风湿关节炎中炎症及关节软骨和骨破坏的影响,可通过调节RANKL/RANK/OPG信号通路实现,也可直接刺激破骨细胞前体分化为破骨细胞实现,继而对类风湿关节炎的发生发展产生重要影响,本文主要综述目前IL-17和RANKL/RANK/OPG通路与类风湿性关节炎的相关性研究。更多还原

【Abstract】 Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with persistent inflammation of the synovium and destruction of articular cartilage and bone. Its pathogenesis is closely related to various cytokines. Interleukin-17 (IL-17 or IL-17A) is a pleiotropic cytokine produced by T-assisted (Th) 17 cells and is involved in the pathogenesis of various autoimmune and inflammatory diseases including rheumatoid arthritis. The important role of IL-17 in the pathogenesis of RA is receiving more and more attention. The effect of IL-17 on inflammation and articular cartilage and bone destruction in rheumatoid arthritis can be achieved by regulating the RANKL/RANK/OPG signaling pathway, or directly stimulating the differentiation of osteoclast precursors into osteoclasts, and then The occurrence and development of rheumatoid arthritis has an important impact. This article mainly reviews the current correlation between IL-17 and RANKL/RANK/OPG pathway and rheumatoid arthritis.更多还原