【摘要】 他汀类药物在冠心病的各级预防中起重要作用,对调脂、稳定斑块、降低主要心血管不良事件发生率有重要意义,大大改善了冠心病人的生活质量和预后。众多大规模临床试验及相关指南已确立了他汀类药物在心血管病防治中的坚实地位。若无严重副作用或禁忌证,绝大多数有适应证的患者应坚持终身不间断使用他汀类药物。然而有研究显示,他汀类药物在开始使用的第1年停药率最高可达75%。患者在治疗期间突然停用他汀类药物治疗可能会产生"反跳"效应,从而增加心血管不良事件发生率。更多还原

【Abstract】 Statins play an important role in the prevention of coronary heart disease, which is important for regulating lipids, stabilizing plaques, and reducing the incidence of major cardiovascular adverse events, and greatly improving the quality of life and prognosis of patients with coronary heart disease. Numerous large-scale clinical trials and related guidelines have established a strong position for statins in the prevention and treatment of cardiovascular diseases. In the absence of serious side effects or contraindications, the vast majority of patients with indications should continue to use statins for life without interruption. However, studies have shown that statins can be stopped up to 75% in the first year of use. Sudden withdrawal of statin therapy during treatment may have a "rebound" effect, which increases the incidence of cardiovascular adverse events.更多还原