【摘要】 目的探讨颅脑损伤患者术后癫痫的发作情况以及丙戊酸钠预防性抗癫痫发作的临床效果。方法选取2016年1月至2018年1月我院收治的164例颅脑损伤患者,随机分成观察组与对照组,每组均各有82例。其中给予观察组患者术前、术中、术后丙戊酸钠预防性抗癫痫治疗,对照组患者不进行预防性抗癫痫治疗。需要观察并计算出患者术后1个月内的癫痫发生率、不同损伤类型患者癫痫发生率、不同损伤严重程度患者癫痫发生率;最后比较两组患者在术后1个月内的癫痫发生率。结果在164例颅脑损伤患者中,一共有32例患者在术后1个月内癫痫发作,发生率为19.51%。闭合性脑损伤患者术后癫痫发生率(5.0%)低于开放性脑损伤(42.2%),差异有统计学意义(P<0.01);重度颅脑损伤患者术后癫痫发生率(39.3%)显著高于轻中度颅脑损伤患者(7.8%),差异有统计学意义(P<0.01)。观察组患者术后1个月癫痫发生率(1.2%)显著低于对照组(37.8%),差异有统计学意义(P<0.01)。结论术前、术中、术后给予患者丙戊酸钠预防性抗癫痫治疗,可明显降低患者术后癫痫的发生率,对促进患者快速康复,具有临床推广的意义。更多还原

【Abstract】 Objective to investigate postoperative epileptic seizure of craniocerebral injury patients and clinical effect of valproate prophylactic preventing epileptic seizures. Methods choose 164 cases craniocerebral injury patients admitted in our hospital from January 2016 to January 2018, divide them into observation group and control group randomly, 82 cases in each. Observation group was treated with preventive antiepileptic treatment with sodium valproate before, during and after operation, while control group with no preventive antiepileptic treatment. Observe and calculate epilepsy incidence within 1 month after operation, epilepsy incidence of different injury types and that of different injury severity. Finally, compare epilepsy incidence of two groups within 1 month after operation. Resultsamong 164 cases craniocerebral injury patients, 32 cases had seizures within 1 month after operation, with incidence of 19.51%. Epilepsy incidence of closed craniocerebral injury(5%) was lower than open craniocerebral injury(42.2%), difference was statistically significant(P< 0.01), postoperative epilepsy incidence of severe craniocerebral injury(39.3%) was significantly higher than mild and moderate craniocerebral injury(7.8%), difference was statistically significant(P < 0.01). Epilepsy incidence of observation group 1 month after operation(1.2%) was significantly lower than control group(37.8%), difference was statistically significant(P< 0.01). Conclusion preoperative, intraoperative and postoperative antiepileptic treatment of sodium valproate can reduce postoperative epilepsy incidence and promote fast recovery of patients significantly, which is of significance in clinical promotion.更多还原