【摘要】 目的分析帕金森病患者的血压变异性与病情严重程度的相关性。方法随机选取我院自2012年7月至2016年6月住院及门诊诊治的帕金森病患者共110例,作为研究组,同时选取同一时期健康人共50例作为健康组,将研究组患者按照H-Y分级进行分组,包含轻症组(H-Y分级为1-2.5级)和重症组(H-Y分级为3-5级),然后按照血压类型进行分组,包含杓型组(为杓型血压)和其他组,各组研究对象均进行24 h动态血压监测,记录并比较各组的24h动态血压各指标和血压变异性,分析帕金森病患者的血压变异性同H-Y分级和UPDRS评分的相关性。结果研究组患者的24 h MBP、n MBP、n SBP、24 h SBP、d SBP和n DBP比健康组的明显增加(P<0.05);杓型组患者的n DBP、n MBP和n SBP比其他组的明显降低(P<0.05);重症组患者的24 h MBP、n DBP、n MBP和n SBP比轻症组的明显增加(P<0.05);研究组患者的夜间血压变异性同H-Y分级和UPDRS评分均呈明显的正向相关性(P<0.05)。结论帕金森病患者会伴有自主神经功能异常,夜间血压变异性同患者的病情程度和运动症状相关,提示临床中可辅助24 h动态血压监测评估病情。更多还原

【Abstract】 Objective to analyze correlation between blood pressure variability and severity of Parkinson’s disease. Methods choose 110 cases Parkinson’s disease patients random Ly from July 2012 to June 2016 in hospitalization and outpatient service of our hospital as study group, and 50 cases healthy people as health group at the same period. Divide study group into groups according to H-Y classification, including light syndrome group(H-Y classification of 1-2.5 levels) and severe group(H-Y classification of 3-5 levels), divide them into groups according to blood pressure type, including dipper group(dipper type blood pressure) and other group. Monitor objects with 24 h dynamic blood pressure, record and compare indexes and blood pressure variability of 24 h dynamic blood pressure in each group, and analyze correlation between blood pressure variability and H-Y classification and UPDRS scores of Parkinson patients. Results 24 h MBP, n MBP, n SBP, 24 h SBP, d SBP and n DBP of study group was significantly higher than healthy group,(P < 0.05). NDBP, n MBP, and n SBP of dipper group was significantly lower than other groups(P < 0.05). 24 h MBP, n DBP, n MBP and n SBP of severe group increased significantly than light syndrome group(P< 0.05). Nocturnal blood pressure variability of study group was positively correlated with H-Y classification and UPDRS scores(P< 0.05). Conclusion Parkinson’s disease patients are associated with abnormal autonomic nervous function, nocturnal blood pressure variability is associated with severity and exercise symptoms of patients, suggesting assisted 24 h dynamic blood pressure monitoring to assess disease condition in clinical practice.更多还原