【摘要】 目的探讨促排卵前男方精子形态参数对常规体外受精-胚胎移植(IVF-ET)妊娠结局的预测价值和影响。方法将502个常规IVF-ET治疗前男方的正常形态精子百分率进行分组,分别为A组:<4%,B组:≥4%~<15%,C组:≥15%,比较各组间的精子功能参数和其IVF-ET周期中的受精率、正常受精率、卵裂率、优胚率、种植率及妊娠率等指标是否有差异。结果 (1)各组间的精液量无差异(P>0.05),而精液密度及前向运动精子百分率差异有显著性(P<0.01);(2)各组间的受精率、卵裂率及优胚率等指标差异均无显著性(P>0.05),仅有<4%组的受精率略低于其它两组,而≥15%组的正常受精率略高于其它两组;(3)各组间的种植率、生化与临床妊娠率、异位妊娠率、早期与晚期流产率及活产率均无显著差异(P>0.05)。但早期流产率随正常形态精子百分率的增加而呈逐渐下降趋势。结论精子形态与其功能密切相关;仅通过精子形态检测来预测IVF-ET的妊娠结局有一定的局限性。更多还原

【Abstract】 Objective To study the predictive value and effects of the sperm morphological parameters on the pregnancy outcome of normal in-vitro fertilization embryo transfer(IVF-ET) before ovulation induction. Methods Divide the sperm percentages of 502 normal male sperms before normal in-vitro fertilization embryo transfer(IVF-ET) into 3 groups: Group A: < 4%, Group B ≥4%~<15% and Group C: ≥15%; and then compare the functional parameters of different groups of sperm and their fertilization rates, normal fertilization rates, cleavage rates, good-quality embryo rates, implantation rates and pregnancy rates during the IVF-ET process. Results(1) No differences in semen volumes between the three groups(P>0.05), but significant differences in sperm density and the percentage of sperms swimming forward(P<0.01);(2)No apparent differences in fertilization rates, cleavage rates and good-quality embryo rates, implantation rates(P>0.05), only the fertilization rates of Group A are slightly lower than those of other two groups, whereas the normal fertilization rates of Group C are slightly higher than those of other two groups;(3) No significant differences in implantation rates, biological and clinical pregnancy rates, early and late abortion rates, and live birth rates(P>0.05). Conclusion Though the morphology of sperm is closely related with its functions, prediction of pregnancy outcome of IVF-ET merely by sperm morphology is not entirely reliable.更多还原