【摘要】 通过5-甲基/氨基-1H-四唑乙酸与(R3Sn)2O(R为苯基或正丁基)及三环己基氢氧化锡的反应,合成了5个三有机锡5-甲基/氨基-1H-四唑乙酸酯。通过核磁,红外及X射线单晶衍射分析,对这些化合物进行了详细的结构表征。结果表明,这些化合物往往通过分子间的Sn…N作用形成配位高分子。初步的生物活性测试表明,这些配合物对Hela和A549细胞具有明显的体外细胞毒性。更多还原

【Abstract】 Five triorganotin 5-methyl-1 H-tetrazolyl-1-acetates and 5-amino-1 H-tetrazolyl-1-acetates have been synthesized by the reaction of(R3 Sn)2 O(R=Ph or n-Bu) or Cy3 Sn OH(Cy=cyclohexyl) with 5-methyl-1 H-tetrazolyl-1-acetic acid or 5-amino-1 H-tetrazolyl-1-acetic acid. All the complexes were characterized by elemental analysis,IR and multinuclear NMR(1 H,13 C and119 Sn). Their structures have been confirmed by the X-ray single crystal diffraction analysis, suggesting that they form linkage coordination polymers through the intermolecular Sn … N interactions. The cytotoxic activity of the complexes for Hela and A549 cells was tested, showing that most of them displayed good cytotoxicities for these two cells in vitro.更多还原