【摘要】 目的测定首发未治疗重度抑郁症(MDD)患者的CT值并探讨其与临床特征的相关性,为MDD的临床诊疗提供参考。方法 2016年1月-2017年6月,采用随机数字表法于佛山市第三人民医院抽取首发未治疗MDD患者(患者组)和健康体检者(对照组)各50例。对两组进行颅脑CT扫描,测定两组各脑叶的CT值;采用汉密尔顿抑郁量表24项版(HAMD-24)评定患者组的抑郁症状。结果患者组左、右额叶及左颞叶CT值低于对照组,差异均有统计学意义(P <0. 05或0. 01);两组其他各脑叶CT值比较,差异均无统计学意义(P均> 0. 05)。患者组各脑叶CT值均与年龄呈负相关,左额叶CT值与病程呈负相关(P均<0. 05),各脑叶CT值与HAMD-24评分、发作次数无相关性(P均> 0. 05)。结论 MDD患者左、右额叶及左颞叶CT值均低于健康人,且脑叶CT值与患者年龄、病程有关,MDD的发病机制可能与部分脑区有关。更多还原

【Abstract】 Objective To measure the CT value of first-episode untreated patients with major depressive disorder(MDD)and to explore the correlation between clinical features,to provide references for diagnosis and treatment of MDD. Methods Total 50 first-episode untreated patients with MDD( patient group) and 50 healthy controls( control group) were selected by random number table method from January 2016 to June 2017 in The Third People’s Hospital of Foshan. All participant were accepted CT scanning of brain and the CT value of lobes were measured. The Hamilton Depression Scale-24 item( HAMD-24) was used to assess the depressive symptoms of the patients. Results The CT values of left frontal lobe,right frontal lobe and left temporal lobe in the patient group were lower than those of control group,the differences were statistical significance( P < 0. 05 or 0. 01). The CT values of other lobes between the two groups were not statistically significant(all P > 0. 05). In patient group,the CT value of each lobe was negatively correlated with the age,the CT value of left frontal lobe was negatively correlated with the duration of disease( all P < 0. 05),there was no correlation between CT value of each lobe with HAMD-24 score and number of attacks( all P > 0. 05). Conclusion The CT values of left frontal lobe,right frontal lobe and left temporal lobe in MDD patients are lower than healthy people. The CT value of lobe is related to the age and duration of disease. The pathogenesis of MDD may be related to some brain regions.更多还原