The supercritical CO_2 extraction of polyphenol from jackfruit seed was optimized by single-factor and orthogonal experiment. Experimental results showed that the successive order of different effect factors on yield of polyphenol was flow rate of CO_2> extracting temperature > ethanol concentration > ethanol dosage > extracting pressure. The optimal exterimental parameters were 30 g·min~(-1) flow rate of CO_2,175 bar extracting pressure、70% ethanol concentration、5 mL/g ethanol dosage、50 ℃ extracting temper...