【摘要】 细胞焦亡(pyroptosis)是促炎形式的程序性细胞死亡,并且依赖于半胱氨酸天冬氨酸特异性蛋白酶(caspases)活性。由caspases通过切割gasermin D(GSDMD)的氨基端和羧基端的连接体调控,后者移位到膜上并穿孔,诱导水分渗透,细胞肿胀并释放炎性因子,继而发生细胞焦亡。细胞焦亡的形态学特征、发生及调控机制等均不同于凋亡、坏死等其他细胞死亡方式,其是机体一种重要的天然免疫反应,在抗击感染以及疾病中均有重要作用。通过对细胞焦亡的更深入研究,可以认知其在相关疾病中的作用,为临床提供新的治疗思路。更多还原

【Abstract】 Pyroptosis is a pro-inflammatory form of programmed cell death, and which is dependent on the activity of the caspases acid-specific proteases. Coupling of the amino-terminal and carboxy-terminal linkers of gasdermin D(GSDMD) by caspases, the latter is displaced onto the membrane and perforated, inducing moisture penetration, cell swelling and release of inflammatory factors, which is followed by pyroptosis. The morphological features, occurrence and regulation mechanisms of pyroptosis are different from other cell death modes, such as apoptosis and necrosis. It is an important natural immune response in body and plays an important role in fighting infections and diseases. A more in-depth study of pyroptosis can recognize its role in related diseases and provide new therapeutic ideas for clinic treatment.更多还原