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颞叶癫痫患者的睡眠特征研究

Study of sleep features in patients with temporal lobe epilepsy

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【作者】 毛汕潘立平任艳苹曹娟吴丹宋毅军

【Author】 MAO Shan;PAN Li-ping;REN Yan-ping;CAO Juan;WU Dan;SONG Yi-jun;Department of Neurology,Tianjin Medical University General Hospital;Tianjin Neurological Institute;Baodi Clinical College of Tianjin Medical University;

【机构】 天津医科大学总医院神经内科天津市神经病学研究所天津医科大学宝坻临床学院神经内科

【摘要】 目的通过多导睡眠监测(PSG)研究颞叶癫痫(TLE)患者发作间期的睡眠特征。方法选取25例TLE患者为TLE组,健康志愿者18例为对照组,对2组受试者分别进行PSG,监测指标包括总卧床时间(TIB)、总睡眠时间(TST)、睡眠效率(SE)、睡眠潜伏期(SL)、快速动眼睡眠期潜伏期(REML)、入睡后觉醒时间(WASO)、非快速动眼睡眠(NREM)1、2、3期以及快速动眼睡眠期(REM)时间占总睡眠期时间的百分比(以N1%、N2%、N3%、REM%表示)、呼吸暂停低通气指数(AHI)、低通气指数、平均血氧饱和度(Sp O2)及最低Sp O2、觉醒指数、每小时周期性肢体运动指数(PLMs/h)、每小时REM期PLMs、总睡眠期转换次数(SSS)、每小时睡眠期转换次数(SSS/H)、NREM1、2、3期以及REM、清醒期转换次数(以N1、N2、N3、REM、W表示)、N1、N2、N3、REM、清醒期转换次数占总睡眠期转换次数百分比(以N1/SSS、N2/SSS、N3/SSS、REM/SSS、W/SSS表示)等睡眠指标。结果与对照组相比,TLE组WASO延长,平均Sp O2降低,PLMs增多,REM期PLMs增多,SSS、SSS/H及N2增多(P<0.05)。结论 TLE患者存在睡眠障碍,主要表现为睡眠结构明显紊乱,睡眠相关呼吸、运动事件增多。

【Abstract】 Objective To study sleep characteristics in patients with temporal lobe epilepsy(TLE) throughpolysomnography(PSG).MethodsTwenty-five TLE patients(TLE group) and eighteen healthy volunteer subjects(controlgroup) were recruited to our study. Patients of two groups were evaluated by whole-night PSG, including total time in bed(TIB), total sleep time(TST), sleep efficiency(SE), sleep latency(SL), rapid eye movement latency(REML), wake after sleeponset(WASO), the percentages of non-REM(NREM) 1, 2 and 3 stages and the percentages of rapid eye movement(REM)occupied TST(N1%, N2%, N3% and REM%), the apnea-hypopnea index(AHI), hypopnea index, mean oxygen saturation(Sp O2) and nadir Sp O2, periodic leg movements(PLMs) index and PLMs index of REM sleep, sleep stage shifts(SSS) andsleep stage shifts per hour(SSS/h), NREM1, NREM2, NREM3 and REM sleep stage and wake shifts(abbreviated as N1, N2,N3, REM and W) and their proportions of SSS(abbreviated as N1/SSS, N2/SSS, N3/SSS, REM/SSS and W/SSS).Results Compared with control group, WASO, PLMs, PLMs index of REM sleep, SSS, SSS/H and N2 were significantly increased inTLE group. Moreover, compared with control group, Sp O2 was decreased in TLE group(P<0.05).ConclusionOur resultssuggest that TLE patients have sleep disorder manifested as disorder of sleep structure, increased incidents of respiratory andmotion events.

【基金】 天津市应用基础与前沿技术研究计划(14JCZDJC35400);2016年度天津市“131”创新型人才团队培养工程
  • 【文献出处】 天津医药 ,Tianjin Medical Journal , 编辑部邮箱 ,2018年01期
  • 【分类号】R742.1
  • 【被引频次】3
  • 【下载频次】109
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