【摘要】 目的综合评价干扰素诱导跨膜蛋白3(IFITM3)基因遗传变异rs12252对流感发病及严重程度的影响。方法全面检索相关中外文数据库,收集2018年6月前发表的有关rs12252遗传变异与流感易感性及严重程度的人群关联研究。使用Stata 14.0软件进行统计分析。结果最终11项研究经筛选纳入分析。结果显示rs12252T>C遗传变异显著增加流感发病风险。其显性模型、隐性模型、等位基因模型下的相对危险度(OR)及95%置信区间(95%CI)分别为1.64(1.22～2.22)、2.76(1.71～4.43)和1.69(1.32～2.18)。同时,该遗传变异还与流感的严重程度显著相关。其显性模型、隐性模型、等位基因模型下的OR及95%CI分别为1.91(1.08～3.39)、2.49(1.14～5.42)和1.85(1.23～2.79)。结论 rs12252T>C遗传变异与流感发病和重症化风险增加显著相关。更多还原

【Abstract】 Objective To comprehensively evaluate the association of the interferon-inducible transmembrane protein 3(IFITM3)genetic variant rs12252 with influenza susceptibility and severity.Methods Relevant studies published before June 1,2018 were retrieved from PubMed,web of science,OVID,CNKI,CBM and Wanfang databases.Data from these studies were analyzed using Stata 14.0.Results A total of 11 studies were finally included in the meta-analysis.Our results showed that rs12252 T>C alteration increased the risk of influenza significantly.The odds ratio(OR)and 95%confidence interval(95%CI)were 1.69(1.32-2.18),1.64(1.22-2.22)and 2.76(1.71-4.43)under the allelic,dominant and recessive models,respectively.Moreover,rs12252 T>C was associated with severity of influenza,and the ORand 95% CIof three models above were 1.85(1.23-2.79),1.91(1.08-3.39)and 2.49(1.14-5.42),respectively.Conclusion Our meta-analysis suggests that IFITM3 rs12252 T>C genetic variant is significantly associated with increased risk and severity of influenza.更多还原