【摘要】 目的:探讨随机尿微量白蛋白与肌酐比值在2型糖尿病早期肾损伤诊断中的临床应用价值。方法:以459例2型糖尿病患者及97例健康体检者为研究对象,采用速率散射比浊法测定随机尿中微量白蛋白(m ALB)和肌酐(Cr)含量,并计算m ALB与Cr的比值(ACR)。与24 h微量尿白蛋白定量结果进行线性回归分析,确定其相关性。以尿白蛋白排泄率>20 mg/24 h为诊断标准,计算ACR诊断糖尿病肾病的特异性和灵敏度,并初步确定其医学决定水平。结果:随机尿ACR与24 h尿微量白蛋白定量值相关性分析r=0.738(P<0.01)呈正相关,具有统计学意义,ACR的医学决定水平为2.285 mg/mmol。结论:ACR高于2.285 mg/mmol时,提示医生进行早期干预治疗。更多还原

【Abstract】 Objective: To investigate the value of urinary albumin to creatinine ratio(ACR) for early diagnosis of type 2 diabetic nephropathy. Methods: The microalbumin(m ALB) and creatinine(Cr) content in random urine of 459 type 2 diabetic patients nephropathy and 97 healthy people was detected through immunoturbidimetric assay, and the ratio of m ALB to Cr(ACR) was determined.Linear regression analysis was used to determine the correlation between the results of ACR and urine persistant m ALB. Urinary protein excretion rate >20 mg/min was set as the diagnostic criteria to calculate the specificity and sensitivity of ACR in the diagnosis of diabetic nephropathy, and the medical decision level was preliminarily determined. Results: The correlation analysis between random urine ACR and 24 h urine albumin showed a positive correlation between them, with statistical significance [r =0.738(P <0.01)], and the medical decision level of ACR was 2.285(mg/mmol). Conclusion: When ACR is higher than 2.285(mg/mmol), doctors should perform early intervention.更多还原