【摘要】 目的比较7种常见高危型HPV亚型感染与宫颈癌及高级别病变的相关性。方法收集2014年1月至2016年10月在宁波市妇女儿童医院妇科接受宫颈组织学检查的1 195例患者HPV16、18、31、33、35、52、58感染情况。采用Logistic回归方法分析上述各种高危型HPV亚型感染与宫颈癌及宫颈高级别病变的相关性。结果在7种HPV亚型感染病例中,宫颈癌的检出率排序从高到低为:HPV18(5.78%)、HPV16(5.39%)、HPV58(1.71%)、HPV31(1.35%)、HPV52(0.39%)、HPV33(0%)、HPV35(0%),宫颈高级别病变的检出率排序从高到低分别为:HPV33(48.04%)、HPV16(47.86%)、HPV58(29.56%)、HPV31(24.65%)、HPV18(23.31%)、HPV35(22.58%)、HPV52(21.26%)。HPV16型感染时患宫颈癌的风险最大(OR=3.831,P<0.05),HPV18型次之(OR=2.586,P<0.05);HPV16型感染时患宫颈高级别病变的风险也最大(OR=2.880,P<0.05),HPV33型次之(OR=2.531,P<0.05)。结论不同亚型的高危型HPV感染与宫颈癌及高级别病变的相关性不同;HPV16、18型感染与宫颈癌的相关性较大,HPV16、33型感染与宫颈高级别病变的相关性较大。更多还原

【Abstract】 Objective To examine the correlation between high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions. Methods From January 2014 to October 2016,a total of1 195 HPV infected patients admitted at Ningbo Women’s & Children’s Hospital were enrolled in this study. The HPV subtypes involved in this study were HPV16,18,31,33,35,52 and 58. All cases had a confirmed cervical pathological result. Univariate analysis and multivariate Logistic regression analysis was used to analyze the correlation between the high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions. Results The detection rates of cervical cancer in seven HPV subtypes infection cases were: HPV18( 5. 78%),HPV16( 5. 39%),HPV58( 1. 71%),HPV31( 1. 35%),HPV52( 0. 39%),HPV33( 0%) and HPV35( 0%). The detection rates of high-grade cervical lesions in seven HPV subtypes infection cases were: HPV33( 48. 04%),HPV16( 47. 86%),HPV58( 29. 56%),HPV31( 24. 65%),HPV18( 23. 31%),HPV35( 22. 58%) and HPV52( 21. 26%). The risk of cervical cancer in the case of HPV16 infection was the greatest( OR= 3. 831,P<0. 05),followed by HPV18 infection( OR= 2. 586,P<0. 05). The risk of high-grade cervical lesions in the case of HPV16 infection was still the greatest( OR = 3. 831,P<0. 05),followed by HPV33( OR = 2. 531,P<0. 05).Conclusion The correlations between various high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions are different. HPV16 and 18 infection are likely to be associated with cervical cancer,while HPV16 and 33 infection are likely to be associated with high-grade cervical lesions.更多还原