【摘要】 哺乳动物卵泡发育研究对于辅助生殖技术的发展具有重要意义。随着分子生物学技术的发展,哺乳动物卵泡发育研究主要放在对其调控的分子机制中。本文重点阐述了与卵泡发育相关的激活素/抑制素作用通路、BMP/Smad信号通路以及NPPC/NPR2信号通路,以期对哺乳动物不孕发生的原因及治疗提供参考。更多还原

【Abstract】 Better understanding of follicular development in mammals is the key to improve assisted reproductive technologies. With the development of molecular biology techniques,the study of mammalian follicle development mainly focuses on the molecular mechanismof its development. In this review,we summarizedthat the most important signaling pathways,including the activator/inhibin pathway,BMP/Smad signaling pathway and NPPC/NPR2 signaling pathway,which play key roles in the follicular development and provide the potential therapeutic targets to investigate the causes and treatment of infertility in mammals.更多还原