【摘要】 目的:探讨5-氟尿嘧啶联合地塞米松对翼状胬肉术后复发的防治效果。方法:选取2014年1月～2016年6月本院收治的初发性翼状胬肉患者170例(210眼),随机分为对照组A(5-氟尿嘧啶组)58例(70眼)、对照组B(妥布霉素地塞米松滴眼液组)56例(70眼)、观察组(5-氟尿嘧啶+地塞米松)56例(70眼)。对术后复发率、泪膜功能、患者舒适度及并发症进行比较分析。结果:观察组术后复发率明显低于对照组A和对照组B(χ~2=3.905、4.763,均P<0.05);三组患者术前、术后3个月BUT和SIT之间比较差异不明显,均P>0.05;三组患者术后1个月BUT和SIT之间比较差异显著(F检验值依次为4.834、3.827,均P<0.05),其中观察组的BUT和SIT均明显高于对照组A和对照组B,均P<0.05;术后1周、1个月三组患者舒适度评分之间比较具有统计学差异均P<0.05,其中观察组术后1周、1个月舒适度评分显著低于对照组A和对照组B,均P<0.05。术后3个月三组患者舒适度评分之间比较不具有统计学差异(P>0.05)。结论:5-氟尿嘧啶联合地塞米松对翼状胬肉术后复发具有更有效的防治作用,对眼表无明显药物性损害,可为临床药物防治翼状胬肉术后复发提供新的治疗方法。更多还原

【Abstract】 Objective: To study the effect of 5-Fluorourac il combined Dexamethasone on the prevention and treatment of postoperative recurrence of pterygium. Methods: 170 patients(210 eyes) with primary pterygium were selected from Jan 2014 to Jun 2016 in the hospital, randomly divided into the control group A(5-Fluorouracil group) 58 cases(70 eyes), the control group B(Tobramycin Dexamethasone gutta group) 56 cases(70 eyes) and the observation group(5-Fluorouracil+ Dexamethasone group) 56 cases(70 eyes).Recorded and compared the postoperative recurrence rate, tear film function and patients comfort and complications. Results: The recurrence rate of the observation group after surgery was significantly lower than the control group A and control group B(The values of χ~2 were 3.905,4.763 respectively, all P<0.05); There was no significant difference in BUT and SIT between preoperative and postoperative3 months in the three groups of patients(all P >0.05); The three groups of patients after operation 1 month, SIT and BUT were significantly different(The values of F were 4.834, 3.827, all P<0.05), the observation group’s BUT, SIT were significantly higher than the control group A and control group B(both P<0.05). After 1 week, 1 month comfort score of three groups were statistically significant(all P<0.05). In the observation group, 1 week, 1 month comfort score of the observation group after the operation were significantly lower than that of the control group A and control group B(P<0.05). 3 months after the operation compared with the three group’s comfort score was not statistically significant(P>0.05). Conclusion: 5-Fluorouracil combined Dexamethasone in the prevention and treatment of recurrence of pterygium after surgery can be more effective, with no obvious drugs damage on ocular surface, can provide a new way to prevent and control the recurrence of pterygium after operation.更多还原