Objective To explore the role and mechanism of activating transcription factor 3(ATF3) in HG-treated podocyte apoptosis. Methods Laser confocal microscopy and Western blotting were used to observed the expression of ATF3 in the db/db mouse of diabetic kidney disease. The conditionally immortalized mouse podoyte cell line was cultured in vitro and exposed to HG(30 mmol/L) for different time points. Real-time quantity PCR and Western blotting were used to analyze the expression of ATF3; Cell apoptosis in ATF3...
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