【摘要】 目的探讨呼出气冷凝液(EBC)、血清中炎症标志物对支气管哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)患者的临床意义。方法选择在我院诊治的慢性气道炎症性疾病患者,随访进入稳定期后纳入临床实验,ACOS患者18例,支气管哮喘(哮喘)22例,慢性阻塞性肺疾病(慢阻肺)24例,同期20例健康非吸烟者为对照组;检测EBC和血清8-异前列腺素(8-iso PG)等炎症因子浓度进行比较分析。结果 ACOS组血清、EBC中8-iso PG浓度均显著高于健康对照组,ACOS组EBC中8-iso PG浓度显著高于哮喘组、慢阻肺组,差异均有统计学意义(P<0.05);EBC中8-iso PG水平与年龄、吸烟指数、体重、FEV1值无明显相关性(P>0.05)。结论 8-iso PG等炎症因子参与了ACOS患者气道炎症过程,EBC中8-iso PG可能具有潜在的鉴别ACOS生物标志物价值,值得进一步研究。更多还原

【Abstract】 Objective To investigate the clinical significance of biochemical markers in EBC and serum inpatients with bronchial asthma and chronic obstructive pulmonary disease overlap syndrome(ACOS). Methods We selected Patients with chronic airway inflammatory diseases in our hospital,These patients underwent clinicaltrial after the stable phase,including 18 ACOS patients,22 asthma patients,24 COPD patients and 20 healthynon-smokers in the same period. 8-iso PG and other inflammatory factors levels in EBC and serum were measured inthe selected patients. A comparative analysis was performed. Results The levels of EBC 8-iso PG in the ACOSgroup were significantly higher than those in the healthy control group,The levels of serum and EBC 8-iso PGin the ACOS group were significantly higher than the asthma group and the COPD group(P < 0.05). The level of8-iso PG in EBC was not related to age,smoking index,weight,and FEV1 value(P > 0.05). Conclusions Inflam-matory factors including 8-iso PG,are involved in chronic inflammation in lung tissues of patients with ACOS.8-iso PG in EBC may have potential value in identifying ACOS from COPD and asthma as biomarkers and deservefurther study.更多还原