目的探讨血清醛固酮(ALD)水平对经皮冠脉内介入治疗(PCI)后12个月内心血管事件和支架内再狭窄(ISR)的预测价值。方法选取2014年1月至2016年7月入住心内科的冠心病患者268例[96例稳定型心绞痛(SAP)和172例急性冠脉综合征(ACS)],PCI术前测定基础血清ALD水平。将患者分为ALD<130 pg/m L(127例)和ALD≥130 pg/m L(141例)两组,分析并记录患者术后12个月内心血管事件(心绞痛、心肌梗死及死亡)发生率及ISR(原病变冠脉直径狭窄程度≥50%)等情况。应用Logistic回归分析发生ISR的独立危险因素。结果血清ALD水平在ACS组比SAP组高[(160±58)pg/mL vs.(118±46)pg/m L,P<0.05];PCI术后12个月的心血管事件及ISR发生率ALD高者远高于ALD低者(24.1%vs.3.1%,P<0.05;16%vs.7.4%,P<0.05),Logistic回归分析显示血清ALD水平是发生ISR的最强预测因素(比值比为每10 pg/m L 2.56)。结论基础血清ALD水平是PCI术后12个月内发生心血管事件和ISR的预测指标,...
【英文摘要】
Objective To investigate the value of baseline levels of aldosterone(ALD)in predicting thecardiovascular events and in-stent restenosis 12 months after coronary stent implantation. Methods 268 patientswith coronary heart disease admitted to the department of cardiology from January 2014 to July 2016 were selected(96 cases of stable angina pectoris and 172 cases of acute coronary syndrome). The ALD level in the preproceduralserum was detected before coronary stent implantation. According to the level of ALD,...