【摘要】 目的探讨ABCB1基因C3435T位点多态性与新疆维吾尔族人群癫痫及耐药性的关系。方法选取2017年新疆医科大学第五附属医院收治的住院或门诊维吾尔族癫痫患者98例作为癫痫组,其中耐药性癫痫患者38例,非耐药性癫痫患者60例;另选取同期在本院体检健康的维吾尔族志愿者100例作为对照组。采用聚合酶链反应(PCR)检测ABCB1基因C3435T位点多态性,比较癫痫组与对照组受试者、耐药性癫痫与非耐药性癫痫患者ABCB1基因C3435T位点基因型、等位基因分布频率。结果癫痫组与对照组受试者ABCB1基因C3435T位点基因型、等位基因分布频率比较,差异无统计学意义(P>0.05)。耐药性癫痫与非耐药性癫痫患者ABCB1基因C3435T位点基因型、等位基因分布频率比较,差异无统计学意义(P>0.05)。结论 ABCB1基因C3435T位点多态性与新疆维吾尔族人群癫痫易感性及耐药性癫痫的发生无关。更多还原

【Abstract】 Objective To investigate the association between C3435T polymorphism of ABCB1 gene with epilepsy and drug-resistance in Xinjiang Uygur population. Methods A total of 98 Uyghur patients with epilepsy admitted to the Fifth Affiliated Hospital of Xinjiang Medical University were recruited as epilepsy group in 2017,and 100 healthy individuals were selected as control group. Of the 98 Uyghur patients with epilepsy,38 cases were drug-resistant epilepsy,and the other 60 cases were non-drug resistant epilepsy. C3435T polymorphism of ABCB1 gene was detected by PCR. Genotypes and allele frequency of ABCB1 gene C3435T locus were compared between epilepsy group and control group,in patients with drug-resistant epilepsy or not. Results There was no statistically significant difference in genotypes or allele frequency of ABCB1 gene C3435T locus between epilepsy group and control group(P>0.05). There was no statistically significant difference in genotypes or allele frequency of ABCB1 gene C3435T locus in patients with drug-resistant epilepsy or not(P>0.05). Conclusion There was no association between C3435T polymorphism of ABCB1 gene and genetic susceptibility to epilepsy and drug-resistant epilepsy in Xinjiang Uygur population.更多还原