【摘要】 目的分析血管内支架机械取栓术在缺血性脑卒中急性期患者中的应用效果。方法选取2016年12月—2018年1月石家庄市第一医院收治的缺血性脑卒中急性期患者124例,采用随机数字表法分为对照组和研究组,每组62例。在常规治疗基础上,对照组患者采用静脉溶栓治疗,研究组患者采用血管内支架机械取栓术治疗。两组患者均随访3~6个月,比较两组患者溶栓/取栓前、溶栓/取栓后即刻、溶栓/取栓后10 d美国国立卫生研究院卒中量表(NIHSS)评分,溶栓/取栓后即刻、溶栓/取栓后10 d及随访结束后血管再通率,随访结束后格拉斯哥预后量表(GOS)评分;并观察两组患者溶栓/取栓后10 d内不良反应/并发症发生情况。结果两组患者溶栓/取栓前NIHSS评分比较,差异无统计学意义(P>0.05);研究组患者溶栓/取栓后即刻、溶栓/取栓后10 d NIHSS评分低于对照组(P<0.05)。研究组患者溶栓/取栓后即刻、溶栓/取栓后10 d及随访结束后血管再通率高于对照组(P<0.05)。研究组患者随访结束后GOS评分低于对照组(P<0.05)。研究组患者溶栓/取栓后10 d内不良反应/并发症发生率低于对照组(P<0.05)。结论与静脉溶栓治疗相比,血管内支架机械取栓术能有效减轻缺血性脑卒中急性期患者神经功能损伤程度,提高血管再通率,改善患者短期预后,且安全性较高。更多还原

【Abstract】 Objective To analyze the application effect of endovascular stent mechanical thrombectomy in patients with acute ischemic stroke. Methods A total of 124 patients with acute ischemic stroke were selected in the First Hospital of Shijiazhuang from December 2016 to January 2018,and they were divided into control group and study group according to random number table,each of 62 cases. Based on conventional treatment,patients in control group received venous thrombolytic therapy,while patients in study group received endovascular stent mechanical thrombectomy. Patients in the two groups were followed up for 3 to 6 months,NIHSS score before thrombolysis/thrombectomy,immediately after thrombolysis/thrombectomy and 10 days after thrombolysis/thrombectomy,vascular recanalization rate immediately after thrombolysis/thrombectomy,10 days after thrombolysis/thrombectomy and at the end of follow-up,and GOS score at the end of follow-up were compared between the two groups,and incidence of adverse reactions/complications within 10 days after thrombolysis/thrombectomy was observed. Results No statistically significant differences of NIHSS score was found between the two groups before thrombolysis/thrombectomy(P>0.05),while NIHSS score in study group was statistically significantly lower than that in control group immediately after thrombolysis/thrombectomy and 10 days after thrombolysis/thrombectomy,respectively(P<0.05). Vascular recanalization rate in study group was statistically significantly higher than that in control group immediately after thrombolysis/thrombectomy,10 days after thrombolysis/thrombectomy and at the end of follow-up,respectively(P<0.05). GOS score in study group was statistically significantly lower than that in control group at the end of follow-up(P<0.05). Within 10 days after thrombolysis/thrombectomy,incidence of adverse reactions/complications in study group was statistically significantly lower than that in control group(P<0.05). Conclusion Compared with venous thrombolytic therapy,endovascular stent mechanical thrombectomy can effectively reduce the degree of neurological function damage in patients with acute ischemic stroke,improve the vascular recanalization rate and short-term prognosis,and with relatively hign satefy.更多还原