【摘要】 74岁女性患者,双下肢反复多发肿块伴溃疡6个月。皮损组织病理示:大、中、小3种肿瘤细胞混合浸润,有明显的血管中心性和血管破坏,伴广泛的凝固性坏死和溃疡。免疫表型:CD3ε、CD43、CD56、TIA-1、EB病毒潜伏膜蛋白(EBV LMP-1)、粒酶B(Granzyme B,Gr B)均阳性,Ki-67阳性(≥85%),CD8+>CD4+。全身检查未发现皮肤以外系统受累证据,诊断为原发皮肤结外NK/T细胞淋巴瘤-鼻型。该病恶性程度高,需尽早进行组织病理检查和免疫组化染色以帮助诊断。更多还原

【Abstract】 A 74-year-old woman presented with a 6 months history of repeated multiple masses on both lower limbs with ulceration. The biopsy of the skin lesions showed that: mixed infiltration of large, middle and small tumor cells, with vascular centrality and vascular destruction, as well as extensive coagulation necrosis and ulceration. The result of immunohistochemistry staining: CD3+, CD43+, CD8+>CD4+, Gr B(Granzyme B)+, TIA-1+, Latent membrane protein of EB virus(EBV LMP-1)+, CD56+, Ki-67+(≥85%). There were no signs of systemic involvement. Primary cutaneous extranodal NK/T cell lymphoma-nasal type was diagnosed. The malignant degree of the disease is high. Histopathological examination and immunohistochemical staining should be carried out as early as possible to determine the diagnosis.更多还原