【摘要】 目的探讨磁共振成像(MRI)与B超对甲状腺相关性眼病(TAO)患者病情评估和临床疗效预判的作用及意义。方法选取2011年10月至2013年10月在上海长征医院内分泌科住院的61例TAO患者与16例健康人,MRI测量眼外肌厚度、信号强度比、泪腺横径;B超测量眼外肌厚度。比较两种检查方法对甲状腺相关性眼病的诊断价值。结果 MRI测量的TAO患者双眼下直肌、外直肌厚度明显大于B超测量值(P<0.05)。MRI测量结果与TAO临床活动性评分(CAS)显著正相关,MRI评估TAO的活动性优于B超。MRI检查满足不同指标时,对临床疗效预判的敏感度及特异度可达100%。结论 MRI对TAO患者眼外肌增粗较B超更敏感,MRI的检测结果与CAS和临床疗效密切相关,MRI有利于更准确地早期诊断TAO及预判其治疗转归。更多还原

【Abstract】 Objective To discuss the role and significance of Magnetic resonance imaging(MRI) and B-ultrasonography in the disease evaluation and clinical efficacy prediction of patients with thyroid-associated ophthalmopathy(TAO). Methods Select 61 patients with TAO who were hospitalized in the endocrinology department of Shanghai Changzheng Hospital from October 2011 to October 2013 and 16 cases of healthy people to participate in the experiment. Use MRI to measure the extraocular muscle thickness and the lachrymal diameter, and calculate the signal intensity ratio of subjects. Use B-ultrasonography to measure the extraocular muscle thickness. Result The measurements of muscle thickness of inferior rectus and lateral rectus by MRI were significantly greater than those by B-ultrasonography, the difference being statistically significant. The results of MRI measurements were positively correlated with the CAS score. In evaluating the activity of TAO, MRI was superior to B-ultrasonography. The sensitivity and specificity of the prejudgement of clinical efficacy could reach 100% when the MRI examination met different indicators. Conclution MRI is more sensitive to extraocular muscle thickening than B-ultrasonography in patients with TAO. The results of MRI is closely related to the CAS score and clinical efficacy. MRI is beneficial to more accurate early diagnosis of TAO and the prediction of treatment outcomes.更多还原