【摘要】 目的探讨丹参多酚酸盐辅助治疗对不稳定型心绞痛(UA)患者炎症因子和心功能的影响。方法前瞻性选取从2014年8月至2017年8月收治的152例不稳定型心绞痛患者,按随机数字表法随机均分为两组。对照组76例,给予内科规治疗;观察组76例,在对照组的基础上给予丹参多酚酸盐治疗。治疗1月后,观察比较两组的总有效率、心功能、运动诱发心绞痛的发作时间、6 min步行距离、炎症因子[肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hsCRP)、白细胞介素1(IL-1)]以及药物不良反应等。结果治疗1个月后,观察组和对照组总有效率分别为90.79%和76.32%,观察组明显高于对照组,差异具有统计学意义(P<0.05);两组左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)等心功能指标均明显优于治疗前(P<0.05),且观察组均明显优于对照组,差异具有统计学意义(P<0.05);两组运动诱发心绞痛的发作时间及6 min步行距离均明显长于治疗前(P<0.05),且观察组明显长于对照组,差异具有统计学意义(P<0.05);两组TNF-α、hs-CRP、IL-1炎症因子均明显低于治疗前(P<0.05),且观察组明显低于对照组,差异具有统计学意义(P<0.05);两组不良反应发生率分别为7.89%和10.53%,差异无统计学意义(P>0.05)。结论丹参多酚酸盐辅助治疗UA患者疗效显著,能够有效改善患者心功能、临床症状及降低TNF-α、hs-CRP、IL-1等炎症因子的表达水平,且安全性好,值得推广应用。更多还原

【Abstract】 Objective To explore the effects of salvinolate on TNF-α,hs-CRP,IL-1 and cardiac function in patients with unstable angina pectoris. Methods 152 cases from August 2014 to August 2017 were randomly divided into control group( 76 cases) and observation group( 76 cases) according to random number table method. The control group accepted conventional treatment,including aspirin,statins,clopidogrel,nitrates,ACEI and beta-blockers and so on; while the observation group accepted salvinolate on the base of control group. After the treatment for 1 month,the total effective rate,cardiac function,time of exercise induced angina pectoris,walking distance for 6 mins,serum inflammatory factors( TNF-α,hs-CRP,IL-1) and adverse drug reactions were observed. Results The total effective rates of two group were90. 79% and 76. 32%,the observation group was much higher than the control group,which was significantly different( P < 0. 05). The cardiac functions( LVEF、LVEDD、LVESD) were both significantly better than before( P < 0. 05),and the observation group was much better than the control group( P < 0. 05). The time of exercise induced angina pectoris and distance for 6 mins’ walking were also both significantly longer than before( P < 0. 05),and the observation group was much better than the control group( P < 0. 05). And the levels of serum inflammatory cytokines including TNF-α,hs-CRP,IL-1 were significantly decreased in both groups( P < 0. 05),and the observation group was significantly lower than that in the control group( P < 0. 05). There was no significant difference in the incidence of adverse reactions( P > 0. 05). Conclusion The treatment of salvinolate in patients with unstable angina pectoris is significantly effective,which can improve cardiac functions,reduce the expressions of inflammation factors and safe for patients,so it is worth of application.更多还原