【摘要】 目的探讨维生素A水平与妊娠期高血压疾病的关系。方法回顾性分析2012年6月至2016年6月在山东省广饶县人民医院产科治疗的90例妊娠期高血压患者的资料,另选45例正常孕产妇为正常组,按照治疗方法将90例高血压组的患者分为维生素A干预组及未干预组,每组各45例。干预组患者接受维生素A干预。检测妊娠期高血压组及正常组孕产妇的孕早期、孕中期、孕晚期血清中维生素A的表达,妊娠期高血压、轻度子痫前期及重度子痫前期的孕产妇维生素A表达,以及维生素A干预后的母婴临床结局的分析。结果在孕早期、孕中期及孕晚期的妊娠期高血压孕产妇血清中,维生素A的表达均明显低于正常人群相应时期的表达,差异具有统计学意义(P<0.05);在妊娠期高血压、轻度子痫前期及重度子痫前期的孕产妇中,维生素A的表达呈现出了逐渐下降的趋势,差异具有统计学意义(χ2=14.535,P=0.003);维生素A干预组患者的新生儿体重为(3.42±0.91)kg、新生儿Apgar评分为(9.50±1.62)分均明显提高,而干预后的新生儿不良临床结局如新生儿窒息(2.22%)、胎儿宫内窘迫(2.22%)、新生儿围产期感染(4.44%)及新生儿病死率(0)等均明显低于未干预组(8.88%,11.11%,13.33%,2.22%),差异均具有统计学意义(P<0.05)。结论维生素A的表达与妊娠期高血压的发病具有密切的关系,妊娠中晚期采用维生素A干预治疗可以改善妊娠结局。更多还原

【Abstract】 Objective To investigate the relationship between vitamin A level and hypertensive disorder complicating pregnancy.Methods A retrospective analysis was conducted on the data of 90 pregnant women with hypertension treated in the People’s Hospital of Guangrao from June 2012 to June 2016.Forty-five normal pregnant women were selected as the normal group.According to the random number method,90 hypertensive patients were divided into vitamin A intervention group and non-intervention group,and intervention group received vitamin A intervention.The expression of vitamin A in the serum of pregnant women with gestational hypertension and normal pregnant women in the first trimester,second trimester and third trimester,the expression of vitamin A in pregnant women with gestational hypertension,mild preeclampsia and severe preeclampsia were detected.Analysis of maternal and infant clinical outcomes after vitamin A intervention were performed.Results In the early stages of pregnancy pregnant in mid and late pregnancy gestational hypertension in maternal serum,the expression of vitamin A were significantly lower than normal expression of the corresponding period(P < 0.05),the difference was statistically significant(P < 0.05);In gestational hypertension,mild preeclampsia and severe preeclampsia maternal,the expression of vitamin A presented the declining trend,chi-square examination showed statistically significant difference(χ2= 14.535,P = 0.003).The weight in the vitamin A intervention group was(3.42 ± 0.91) kg and Apgar score in neonates was(9.50 ± 1.62).The above datas were significantly higher than those of no intervention group.Neonatal adverse clinical outcomes such as neonatal asphyxia(2.22%),fetal distress(2.22%),neonatal perinatal infection(4.44%) and neonatal mortality(0) after intervention were significantly lower than those without Intervention group,the difference was statistically significant(P < 0.05).Conclusion The expression of vitamin A is correlated with the incidence of hypertension during pregnancy,the pregnancy middle-late taking vitamin A intervention can improve the pregnancy outcome.更多还原