【摘要】 目的:研究吡咯喹啉醌(PQQ)通过对全身辐射(TBI)诱导的C57BL/6J小鼠腮腺损伤的保护作用。方法:随机将30只8周龄雌性C57BL/6J小鼠分成3组(n=10):未治疗组;4 Gy TBI组;4 Gy TBI加正常饮食添加PQQ组。4周后,取腮腺组织进行病理学和生化指标的测定。结果:PQQ部分纠正了TBI诱导的腮腺损伤,主要通过多个方面发挥对受损腮腺的辐射保护作用,如促细胞增殖、抑制细胞凋亡和衰老、上调抗氧化能力、清除氧自由基、减少DNA损伤。结论:PQQ可能通过上调抗氧化能力、抑制氧化应激,参与DNA损伤修复作用,从而发挥对TBI诱导腮腺损伤的辐射保护作用。更多还原

【Abstract】 Objective: To investigate the effects of pyrroloquinoline quinone( PQQ) on paratid gland damage induced by total body irradiation( TBI). Methods: 30 female 8-week-old C57 BL/6 J mice were randomly assigned into 3 groups( n = 10) : Untreated; 4 gray( Gy) X-ray radiation and 4 Gy X-ray radiation with additional dietary of PQQ. After 4 weeks,parotid glands tissues were collected for evaluating pathological and biochemical parameters. Results: The results indicated that PQQ partially rescued TBI induced damage of parotid glands. PQQ played radio-protective effects on parotid glands through multiple aspects,such as promoting cell proliferation,inhibiting cell apoptosis and senescence,up-regulating antioxidant ability,scavenging ROS and reducing DNA damage.Conclussion: PQQ plays a radio-protective role in parotid gland damage induced by TBI,possibly via inhibiting oxidative stress and participating in DNA damage repair.更多还原