【摘要】 目的:比较靶控输注异丙酚和异丙酚复合瑞芬太尼2种镇静方法在第三磨牙拔除手术中应用的效果。方法:纳入择期接受第三磨牙拔除手术的患者60例,随机分为2组(n=30):P组,异丙酚组,滴定法靶控输注异丙酚至OAA/S评分3分时进行手术;RP组,异丙酚复合瑞芬太尼组,靶控输注瑞芬太尼目标浓度为1 ng/ml,滴定法靶控输注异丙酚至OAA/S评分3分时进行手术。记录患者的心率、血压、血氧饱和度和呼吸频率和NI指数,记录镇静中相关反应情况以及术后患者满意度和术者评价。结果:呼吸频率和血氧饱和度PR组均低于P组(P<0.05)。2组患者均未发生明显不良反应,患者满意度无差异。结论:在第三磨牙拔除术中,靶控输注异丙酚和靶控输注异丙酚复合瑞芬太尼镇静这两种方法都是安全有效的。在吸氧状态下,靶控输注异丙酚复合瑞芬太尼镇静优于异丙酚镇静。更多还原

【Abstract】 Objective:To compare the sedation induced by target-controlled infusion of propofol with that by propofol-remifentanil in third molar exaction surgery.Methods:60 patients for third molar exaction were divided randomly into 2 groups(n=30):group P(propofol group)and group PR(propofol-remifentanil group).In group P,a titrated infusion of propofol was started until the OAA/S score had reached level 3 in the patients,then the surgery began.In group PR,a infusion of remifentanil with a target plasma concentration of 1 ng/ml and a titrated infusion of propofol was started until the OAA/S score had reached level 3,then the surgery began.In all patients,the heart rate,blood pressure,respiratory rate,oxyhemoglobin saturation and narcotrend index were recorded during the operation.The reactions of the patients in the operation were recorded.The satisfaction of the patients and surgeons was asked.Results:The respiratory rate and the oxyhemoglobin saturation in group PR was lower than those in group P(P<0.05).No obvious adverse reaction was observed in the 2 groups.The satisfaction of the patients in the 2 groups was 30/30 and 30/30(P>0.05).Conclusion:The sedation induced by target-controlled infusion of propofol or propofol-remifentanil in third molar extraction is safe.The sedation under target-controlled infusion of propofol-remifentanil is better than that by propofol when inhalating oxygen.更多还原