【摘要】 对于选择的初始无法手术的结直肠癌肝转移病人,经转化治疗可使10%～30%转为可切除。转化治疗的主要方法包括全身化疗和分子靶向治疗,以及经肝动脉化疗,肝动脉灌注和射频消融等局部治疗,而联合门静脉结扎或栓塞的分期肝切除,联合肝脏分隔及门静脉结扎的二步肝切除术等外科手段可以提高手术切除率。结合多学科团队治疗模式的开展,严格的病例筛选,手术技术的提高和外科治疗策略的不断修订,显著提高了CRLM的手术切除率和预后。根治性切除原发肿瘤和所有的肝转移是唯一潜在的治愈性措施。更多还原

【Abstract】 For selected patients with colorectal liver metastases that are initially unresectable, conversion therapy can turn 10%-30% of them into excision. The main methods for conversion therapy include systemic chemotherapy, molecular targeted therapy and local treatments such as intra-arterial hepatic chemotherapy, hepatic artery infusion and radiofrequency ablation. The resection rate can be improved by the surgical methods such as portal vein embolization/portal vein ligation and associating liver partition and portal vein ligation for staged hepatectomy. The surgical resection rate and prognosis of CRLM in selected patients can be significantly improved with the development of multidisciplinary team mode, the improvement of surgical techniques and the continuous revision of surgical treatment strategy in combination of the strict screening of cases. Radical resection of primary tumors and all liver metastases is the only potential cure for CRLM.更多还原