【摘要】 目的 探讨MR扩散张量成像(DTI)在评估脊髓损伤(SCI)早期扩散微结构异常中的应用价值。方法 本研究以改良后的Allen’s方法复制大鼠SCI模型,实验分为假手术组,轻度、中度和重度脊髓损伤4组。通过DTI观察大鼠不同程度SCI模型早期(6、24、72 h)各向异性分数(FA)、表观扩散系数(ADC)值的变化。结果 大鼠SCI后6 h,FA值开始降低,24 h达到最低(P<0.05),且轻、中、重度损伤组间FA值均有显著性差异(P<0.05)。而ADC值仅在重度损伤组减低,24 h明显降低(P<0.05)。结论 与ADC值相比,FA值能更好地反映SCI的严重程度,且减低程度与损伤的严重程度相关。更多还原

【Abstract】 Objective To investigate the value of diffusion tensor imaging(DTI) in the evaluation of diffuse microstructural changes in early stage of spinal cord injury(SCI) in rats.Methods Improved Allen’ s method was used to make SCI in rats model.The rats were divided in the group of four as control,mild,moderate and severe injury groups respectively.We used DTI parameters [fraction anisotropy(FA) and apparent diffusion coefficient(ADC)] values to observe the spinal cord at different stages(6,24 and 72 hours)after spinal injury in the rats.Results The FA value of the spinal cord began to decrease at 6 hours and reached the lowest at 24hours after SCI(P <0.05).There were significant differences in FA values between mild,moderate,and severe injury groups(P<0.05).However,ADC value was seen decreased only in the severe injury group,which was lowest at 24 hours after SCI(P<0.05).Conclusion Compared with ADC value,FA value can better reflect the severity of spinal cord injury in rats with acute SCI.FA values are correlated with the degrees of injury of spinal cord.更多还原