【摘要】 目的通过对2014—2016年北京地区实验动物微生物、遗传质量抽检结果的回顾总结,为实验动物的生产、管理和检测提供参考。方法按照国家和地方现行实验动物检测标准,由北京市实验动物管理办公室组织对北京地区具备资质的实验动物生产单位进行抽样,委托检测机构质检并发布报告。依据检测数据,对3年中不同级别大小鼠、豚鼠、地鼠、兔、犬、猴、小型猪8个品种的实验动物的质量进行评价分析。结果 3年分别抽检动物120、133、130批次,检出不合格批次为16、17、23批。不合格主要因素为兔、犬、猪免疫不达标(49批),小鼠遗传变异3批,嗜肺巴斯德杆菌阳性1批,豚鼠沙门菌和呼肠孤病毒III型抗体阳性各1批,犬沙门菌阳性1批。结论实验动物质量监测是其质量管理的重要手段,为动物生产管理提供了科学依据。更多还原

【Abstract】 Objective To provide reference to production, management and detection of laboratory animal by analyzing of the recently 3 years’ test result(2014—2016) on microbes and genetics of laboratory animals in Beijing. Method According to national and local standard and relevant law and regulation, Beijing Administration Office of Laboratory Animal organized quality monitoring test for qualified laboratory animal manufacturers. According to the 3-year data from test reports, we can analyze the quality of different kinds of laboratory animal(including mice, rats, guineas, shrews,rabbits, dogs, monkeys and minipigs) in Beijing area.Result From 2014 to 2016, there were 120,133 and 130 batches of random testing annually, while 16,17,23 unqualified batches respectively. The main reason for disqualification is the immunity level dissatisfaction(49 batches in rabbits, dogs and minipigs). There were also 3 batches genetic variation and 1 batch Pasteurella Pneumotropica positive in mice.1 batch Salmonella positive and 1 batch reovirus Ⅲ antibody positive were found in guineas,and 1 batch Salmonella positive was found in dogs.Conclusion Quality monitoring of laboratory animal is the important means for the quality management, and it can provide scientific data for the production and management of laboratory animals.更多还原