【摘要】 目的分析三阴乳腺癌患者临床病理特征及免疫组织化学指标意义,为临床上对三阴乳腺癌患者的治疗提供参考依据。方法选取三阴乳腺癌患者共110例,为研究组,选取同时期收治的非三阴乳腺癌患者共110例,为对照组,对比分析两组患者临床病理特征及预后情况,采用免疫组织化学法,检测两组患者P-gp、ERβ、Ki-67等免疫组织化学指标并进行比较。结果研究组患病年龄、组织学分级、肿瘤直径大小、分化程度、淋巴结状态、病理类型与对照组比较,差异有统计学意义(P <0. 05);研究组的月经状态相对于对照组,差异无统计学意义(P> 0. 05);研究组总体生存率、无复发生存率均低于对照组,差异有统计学意义(P <0. 05); ERβ、Ki-67阳性表达率研究组与对照组对比,差异有统计学意义(P <0. 05); P-gp阳性表达率研究组与对照组对比,差异无统计学意义(P> 0. 05); ERβ阳性表达与患病年龄、组织学分级、肿瘤直径大小存在显著相关性; P-gp、Ki-67阳性表达与组织学分级存在显著差异,差异有统计学意义。结论ERβ、P-gp、Ki-67等免疫组织化学指标可作为预测三阴乳腺癌预后情况的参考指标,对于该病的治疗有重要意义。更多还原

【Abstract】 Objective To analyze the clinicopathological features and immunohistochemical significance of triple-negative breast cancer,and to provide reference for the treatment of patients with triple-negative breast cancer. Methods 110 patients with triple-negative breast cancer were selected as the study group. 110 patients with non-triple-negative breast cancer were selected as the control group. Comparative analysis of clinical pathological features and prognosis of the 2 groups of patients were conclucted. Immunohistochemistry was used to detect and compare the immunohistochemical markers of P-gp,ERβ,and Ki-67 in the2 groups of patients. Results The age,histological grade,tumor diameter,differentiation degree,lymph node status and pathological type of the 2 groups,the difference was statistically significant( P < 0. 05). The menstrual status of the study group was significantly higher than that of the control group( P < 0. 05). The overall survival rate and relapse-free survival rate in the study group were lower than those of the control group,and the difference was statistically significant( P < 0. 05). The positive expression rate of ERβ and Ki-67 in the study group was significantly higher than that in the control group( P < 0. 05). The positive expression rate of P-gp in the study group was not significantly different from that of the control group( P > 0. 05). The positive expression of ERβ was significantly associated with the age of disease,histological grade,and tumor size. There was significant difference between P-gp and Ki-67 positive expression and histological grade,the difference was statistically significant. Conclusion ERβ,Pgp,Ki-67 and other immunohistochemical indicators can be used as a prognostic indicator of the prognosis of triple negative breast cancer,it is important for treatment.更多还原