MYC plays an important biological role and the high expression of MYC may happen in a variety of tumors. MYC inhibitor Omomyc inhibits MYC bounding with other genes or proteins. Omomyc can stop small cell lung cancer cell cycle,induce apoptosis,the mechanism depends on p21. The objective of this article is to review concepts and functions of MYC,to summary the relationship of MYC and tumor,to discuss the mechanism and research progress of MYC inhibitor Omomyc,to explore the principle of Omomyc promoting apo...
Modern Oncology 2018,26(02):0288-0290MYC抑制剂Omomyc可抑制MYC在肿瘤中的高表达。研究表明Omomyc可停滞小细胞肺癌细胞的细胞周期,促进细胞凋亡。本文综述MYC的概念及作用,论述Omomyc的作用机制与研究进展,为癌症治疗提供新思路。1 MYC和肿瘤的关系转录因子MYC既能刺激细胞