【摘要】 目的分析大连市2011~2016年疑似预防接种异常反应(adverse events following immunization,AEFI)的监测结果,评价AEFI监测系统的运转情况。方法通过AEFI监测系统,收集2011~2016年AEFI个案数据,应用Excel2007对AEFI特征及相关指标进行描述性统计学分析。结果 2011~2016年大连市共报告AEFI个案467例,年平均估算报告发生率约4.87/10万。48 h报告率为97.43%,及时调查率为98.46%。0~8月份为全年发病最高峰,共209例,占报告总数的44.75%;2岁以内AEFI病例共378例,占报告总数的80.94%;无细胞百白破疫苗AEFI共142例,占报告总数的30.41%;一般反应401例,占报告总数的85.87%,异常反应43例,占报告总数的9.21%;379例AEFI发生在接种后48 h内,占报告总数的81.16%;无细胞百白破疫苗引起的一般反应最多(133例),占一般反应报告总数的33.17%,麻疹风疹联合减毒活疫苗引起异常反应中最多(12例),占异常反应报告总数的27.91%;发热、红肿、硬结是AEFI报告最多的症状,占报告总数的83.30%。结论大连市2011~2016年AEFI监测系统运转良好,但仍需针对重点疫苗开展强化预防接种的留置观察和随访,提高AEFI监测质量及应急处置能力。更多还原

【Abstract】 Objective To analyze the monitoring result of adverse events following immunization(AEFI) during 2011 ~2016 in Dalian City,Liaoning Province,China and evaluate the operation of AEFI monitoring system. Methods The cases of AEFI during 2011 ~ 2016 in Dalian were collected from AEFI monitoring system. Descriptive statistical analysis was performed on the characteristics and relevant indexes of AEFI by using Excel 2007 software. Results A total of 467 cases of AEFI were reported during the period,and the estimated annual incidence of AEFI was 4. 87 per 100 000 doses.The 48 hour report rate of AEFI was 97. 43%,while the timely investigation rate was 98. 46%. A total of 209 cases were reported from June to August,accounting for 44. 75% of the total cases. A total of 378 cases occurred in the infants at ages of less than 2 years,accounting for 80. 94% of total cases. A total of 142 cases were caused by DTa P,accounting for 30. 41% of the total cases. A total of 401 cases of general reactions were reported,accounting for 85. 87% of the total cases,while 43 cases of adverse reactions reported,accounting for 9. 21%. A total of 379 cases occurred within 48 hours after vaccination,accounting for 81. 16% of the total cases. Most of the general reactions were caused by Da TP(133 cases),accounting for 33. 17% of total cases. However,most of adverse reactions were caused by MR vaccine(12 cases),accounting for 27. 91%. The most frequent symptoms of AEFI included fever, redness and swelling and induration,accounting for 83. 30% of total cases. Conclusion The monitoring system of AEFI in Dalian during 2011 ~2016 run well. However,the retention observation and follow-up of vaccination with key vaccines should be strengthened to improve the quality of monitoring and the ability in emergency handling of AEFI.更多还原