The cDNA full length sequence of STAT(Hs STAT, Gen Bank ID: KY123702) was obtained from Hyriopsis schlegelii first time using the TACE-PCR technique. The full length of Hs STAT is 2752 bp. The lengths of the 5′-untranslated region, 3′-untranslated region, and ORF region are 121, 264 and 2367 bp, respectively, and it encoded 788 amino acids. The protein domain consists of four classical conservative function domains, including STAT_int,STAT_alpha, STAT_bind and SH2. Valine possesses the highest percentage of...
信号转导及转录激活因子(Signal transducerand activator of transcription,STAT)是一种胞浆蛋白,控制很多重要的生物应答,进化上功能保守[1],广泛参与细胞分化、凋亡、免疫调节等众多细胞因子信号转导的重要途径[2]。Awersik等[3]对果蝇的性腺研究发现JAK激酶激活的STAT通路?
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